Overview

• Peer-reviewed findings published September 25 in Nature Communications identify a defined transcriptional program in lymphatic endothelial cells that supports long-term immune memory.
• Researchers used single-cell RNA sequencing, spatial transcriptomics, longitudinal sampling, experimental perturbations, and machine learning to capture dynamic LEC responses.
• The gene-expression signature predicts each cell’s capacity to store antigens, offering a way to estimate immune memory potential across diseases and across species.
• The work was led by the iversity of CoColorado Anschutz team with senior author Beth Tamburini, PhD, and first author Ryan Sheridan, PhD.
• Authors highlight potential paths to tune immune memory for more durable vaccines and therapies, though applications remain prospective and require further validation.