Overview

• Statin therapy was linked with a 39% relative reduction in 28-day all-cause mortality among critically ill sepsis patients.
• Researchers used data from the MIMIC-IV database spanning 2008 to 2019 to form two balanced cohorts of 6,070 patients each.
• Patients treated with statins required an average of three additional hours of mechanical ventilation and 26 extra hours of continuous renal replacement therapy.
• Survival benefits were observed in patients with normal, overweight or obese BMI but not in underweight individuals.
• Investigators call for large, randomized trials to confirm causality and to determine optimal statin dosing and timing in sepsis care.