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Study Links Regular Coffee to Microbiome Diversity and Altered Gut Physiology

Researchers say controlled intervention trials are needed to test whether the observed changes are caused by coffee or could be used to ease constipation.

Overview

  • The University of Copenhagen study, which was reported Wednesday, found habitual coffee drinkers had greater gut bacterial diversity and higher abundance of specific taxa such as Lawsonibacter and Slackia.
  • Fifty participants swallowed a SmartPill® that recorded pH, pressure and contractions and the researchers saw lower small‑intestine pH and more colon contractions in frequent coffee drinkers while overall transit time stayed similar.
  • The team paired objective measures of coffee intake—urinary caffeine metabolites—with stool analysis and SmartPill data across 61 healthy adults monitored for nine days.
  • Authors stress the study is observational and cannot prove causation and they recommend randomized intervention trials that control coffee intake to test direct effects on gut physiology.
  • If causal, the link could point to a non‑drug way to stimulate gut motility for people with constipation but the findings are limited by small sample size, a short monitoring window, and unclear health implications of lower small‑intestine pH.