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22h ago

Study Links Regular Cannabis Use to Vascular Dysfunction and Elevated Heart Risks

Healthy non-tobacco-using adults who smoked marijuana or ate THC edibles exhibited roughly 50 percent lower endothelial function compared with nonusers.

Employees inspect cannabis plants at cannabis grower Hollandse Hoogtes, where regulated cannabis cultivation takes place in a grow center, in Bemmel, Netherlands, on April 1, 2025.
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Sunnyside Chews cannabis edible gummies at a Cresco Labs Inc. facility in Indiantown, Florida, U.S., on Monday, March 28, 2022. A bright spot in the beleaguered legal-cannabis industry may be U.S. multistate operators, which we expect to lead the group's 1Q year-over-year sales growth, largely reflecting their expansion in U.S. state-legal markets. Photographer: Eva Marie Uzcategui/Bloomberg via Getty Images
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Overview

  • The JAMA Cardiology study assessed 55 healthy participants who used cannabis at least three times weekly for a year.
  • Marijuana smokers experienced a 42 percent reduction in blood vessel dilation, while THC-edible users saw a 56 percent decrease versus nonusers.
  • In lab tests, serum from marijuana smokers cut endothelial nitric oxide production by 27 percent, whereas edible users’ serum did not affect cell function.
  • Higher potency and more frequent cannabis use were tied to greater impairment in vascular function across participants.
  • The American Heart Association advises against smoking or vaping any substance, including cannabis, due to potential cardiovascular harm.