Particle.news
Download on the App Store
7 ARTICLES
·
yesterday

Study Links Paternal Age Over 45 to Reduced IVF Success in Donor Egg Cycles

Published in Human Reproduction following its ESHRE debut, the research challenges the maternal-age focus by recommending fertility counseling address male age effects.

Doctor providing compassionate healthcare consultation while young couple patient holding hand, comfort each other after infertile report.
Image
Image
The study covered six IVF centres in Italy and Spain

Overview

  • The study analyzed 1,712 first donor egg IVF cycles conducted from 2019 to 2023 at six centers in Italy and Spain to isolate the impact of male partner age.
  • Couples with male partners over 45 experienced a 23.8% miscarriage rate, compared with 16.3% among those with younger partners.
  • Live birth rates dropped to 35.1% for fathers older than 45 versus 41% for men 45 and under.
  • Researchers attribute these outcomes to age-related sperm changes, including DNA fragmentation, chromosomal abnormalities and epigenetic alterations that can impair embryo development.
  • Presented this week at the ESHRE Annual Meeting and published in Human Reproduction, the findings prompt recommendations that fertility clinics update counseling to include male age considerations.