Overview

• A peer-reviewed analysis in JAMA Network Open used 2000–2024 electronic health records from a large cohort reported at about 151,000 adults with and without traumatic brain injury.
• People with moderate or severe TBI had about a 67% higher risk of later malignant brain tumors than matched controls and mild-TBI cases.
• Absolute risk remained low, with roughly 0.6% of the moderate/severe group developing tumors within several years versus about 0.4% in mild-TBI and control groups.
• Mild TBI, including concussion, was not linked to an increased tumor risk in the study.
• Authors emphasize the findings show an association rather than causation, cite EHR and coding limits, outline hypotheses such as neuroinflammation and metabolic stress, and recommend closer long-term monitoring after serious head injury.