Overview
- The peer-reviewed study in Menopause tracked more than 700 women aged 42 to 58 who were within 36 months of natural menopause over four years.
- Higher baseline waist-to-hip ratio was associated with poorer performance across cognitive measures, with measurable declines in visual attention and executive function.
- Participants were randomized to oral conjugated equine oestrogen, transdermal estradiol, or placebo, and central adiposity did not change hormone therapy effects on cognition, according to co-author Dr Taryn James.
- Researchers point to waist-to-hip ratio as an accessible indicator of metabolic and cognitive risk tied to visceral fat, reduced insulin sensitivity, and inflammatory changes after menopause.
- Clinical experts, including Dr Monica Christmas of The Menopause Society, recommend early lifestyle measures before the menopause transition to help lower long-term health and cognitive risks.