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yesterday

Study Links Fathers Over 45 to Higher Miscarriage Rates in Donor-Egg IVF

Clinics are urged to factor male age into counseling after research revealed a significant drop in live birth rates for fathers over 45

Doctor providing compassionate healthcare consultation while young couple patient holding hand, comfort each other after infertile report.
The study covered six IVF centres in Italy and Spain
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Overview

  • The study analyzed 1,712 donor-egg IVF cycles from 2019 to 2023 across six centers in Italy and Spain.
  • Miscarriage rates reached 23.8% for male partners over 45, compared with 16.3% among younger fathers.
  • Live birth rates fell to 35.1% for fathers over 45, versus 41% for those aged 45 or under.
  • Researchers linked declines to sperm aging factors such as DNA mutations, fragmentation and chromosomal errors impairing embryo development.
  • Findings presented at the ESHRE meeting have prompted experts to call on fertility clinics to include paternal age risks in patient counseling.