Study Links Common Virus to a Subtype of Alzheimer’s Disease

Research suggests cytomegalovirus may travel from the gut to the brain, potentially triggering immune responses associated with Alzheimer’s in some individuals.

• A study published in *Alzheimer’s & Dementia* identifies a potential link between cytomegalovirus (CMV), a common herpesvirus, and a subtype of Alzheimer’s disease.
• Researchers found CMV antibodies and the virus itself in the intestines, spinal fluid, and brains of patients with Alzheimer’s, suggesting a connection through the vagus nerve.
• The study highlights a subtype of Alzheimer’s affecting 25–45% of patients, characterized by hallmark amyloid plaques, tau tangles, and distinct immune responses.
• Scientists believe chronic CMV infection may activate immune cells like microglia, leading to inflammation and neuronal damage associated with Alzheimer’s progression.
• Further research is needed to confirm these findings and explore the potential for antiviral treatments and diagnostic blood tests to address this subtype of Alzheimer’s.

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