Study Links Antidepressants to Faster Cognitive Decline in Dementia Patients

Swedish research suggests SSRIs may accelerate memory loss in dementia, though experts urge caution in interpreting findings.

A study of nearly 18,740 dementia patients found that those prescribed antidepressants, particularly SSRIs, experienced faster cognitive decline compared to non-users.
The antidepressant escitalopram was associated with the most rapid decline, followed by citalopram and sertraline, while mirtazapine showed milder effects.
Researchers caution that the study cannot definitively establish whether the medications or the underlying depression caused the observed decline.
Experts emphasize the need for further research to determine whether specific dementia types or patient subgroups respond differently to antidepressants.
The findings highlight the importance of individualized care and regular medication reviews for dementia patients to balance potential benefits and risks.