Overview

• Researchers identified two neural pathways responsible for fentanyl's addictive properties and withdrawal symptoms.
• The study showed that dopamine-releasing neurons in the VTA are linked to the drug's rewarding effects.
• Withdrawal symptoms are associated with increased activity in neurons in the central amygdala.
• Genetically engineered mice could turn off neurons linked to withdrawal, indicating a potential target for therapy.
• Further research is needed to see if these mechanisms are present in humans and how they interact.