Study Identifies Neural Pathways Behind Fentanyl Addiction and Withdrawal

Research in mice reveals distinct brain circuits for the euphoric and withdrawal effects of fentanyl, offering potential avenues for targeted therapies.

• Researchers identified two neural pathways responsible for fentanyl's addictive properties and withdrawal symptoms.
• The study showed that dopamine-releasing neurons in the VTA are linked to the drug's rewarding effects.
• Withdrawal symptoms are associated with increased activity in neurons in the central amygdala.
• Genetically engineered mice could turn off neurons linked to withdrawal, indicating a potential target for therapy.
• Further research is needed to see if these mechanisms are present in humans and how they interact.

3 Articles

Science News Nature Nature