Overview

• A genome-wide loss-of-function screen pinpointed LRP8 as required for TBEV infection of human cells.
• TBEV’s envelope protein E specifically binds LRP8, which is enriched in neurons and at the blood–brain barrier.
• A soluble decoy blocking LRP8 protected 19 of 20 mice from a lethal TBEV challenge, while untreated animals died.
• Study authors say this is the first identification of a single essential host-cell receptor for a flavivirus.
• TBEV causes more than 10,000 cases annually across Europe and Asia, and researchers highlight prospects for receptor-targeted antivirals alongside the need for further mechanistic and safety studies.