Overview

• A multi-institution team led by Manel Esteller published an integrated genome-to-microbiome analysis of Maria Branyas in Cell Reports Medicine.
• Epigenetic clocks estimated her biological age at roughly 94 years when her documented chronological age was 117.
• Despite very short telomeres and clonal hematopoiesis, she showed low systemic inflammation, efficient autophagy, optimal lipid metabolism, youthful T-cell profiles and preserved cognition.
• Her gut microbiome resembled that of much younger individuals, enriched in beneficial Bifidobacterium, alongside lifelong habits such as daily yogurt, no tobacco or alcohol, regular walking and strong social ties.
• Researchers identified rare protective genetic variants and propose the findings as hypothesis-generating biomarkers and potential targets for promoting healthy longevity, with replication studies needed.