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6d ago

Study Finds Men Face Double the Mortality Rate of Women from Broken Heart Syndrome

Research highlights persistent high death rates, severe complications, and calls for improved treatments for Takotsubo cardiomyopathy.

A couple relaxes on Carmel Beach. A new study published in the Journal of the American Heart Association finds that men are more than twice as likely as women to die from takotsubo cardiomyopathy, also known as broken heart syndrome. 
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A couple walks under an umbrella at Pier 39 in San Francisco. A new study published in the Journal of the American Heart Association finds that men are more than twice as likely as women to die from takotsubo cardiomyopathy, also known as broken heart syndrome. 
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Overview

  • A U.S. study analyzing nearly 200,000 hospitalizations from 2016–2020 found the in-hospital mortality rate for broken heart syndrome remained at 6.5%, with no improvement over time.
  • Men hospitalized with the condition faced an 11.2% mortality rate, more than double the 5.5% rate seen in women, despite women comprising 83% of cases.
  • Triggered by acute emotional or physical stress, Takotsubo cardiomyopathy mimics heart attack symptoms and can lead to severe complications, including heart failure, stroke, and cardiac arrest.
  • Age, race, and socioeconomic factors influence vulnerability, with adults aged 46–60 showing an increased incidence compared to younger age groups.
  • Researchers emphasize the urgent need for targeted therapies, improved management strategies, and deeper investigation into the condition's mechanisms and sex-based disparities.