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2h ago

Study Finds Bone Breakdown Follows the Body’s Clock, Not Bone Formation

A constant‑routine protocol with frequent sampling isolated an internal resorption rhythm, prompting calls to test older and shift‑working populations.

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Overview

  • University of Surrey and University of Sheffield researchers tracked bone turnover in 22 healthy young adults over 26 hours under tightly controlled laboratory conditions.
  • sCTX, a marker of bone resorption, showed a circadian pattern, whereas sPINP, a marker of bone formation, did not display an intrinsic daily rhythm.
  • The constant routine design allowed authors to distinguish circadian timing from diurnal variations driven by behaviors and environment.
  • The peer‑reviewed findings appear in Scientific Reports (Darling et al., 2025; DOI: 10.1038/s41598-025-16722-x).
  • Experts, including the Royal Osteoporosis Society, say the work raises testable questions about whether circadian misalignment in shift workers or older adults affects bone density and osteoporosis risk.