Overview

• Texas Tech University Health Sciences Center scientists reported the findings in Fluids and Barriers of the CNS, using the Tg2576 amyloid‑producing mouse line.
• An isotopically labeled sucrose tracer combined with LC-MS/MS and laser microdissection detected extremely low brain penetration across ages and regions.
• Tight junction proteins remained mostly preserved, including in tissue adjacent to amyloid plaques, indicating only limited, localized changes if any.
• The results challenge assumptions of widespread BBB leakiness in Alzheimer’s models and suggest therapies must be designed to cross an intact barrier.
• The team cautioned the findings are model-specific and plans to test rodent versions of FDA‑approved monoclonal antibodies to probe whether treatment-related microhemorrhages or swelling cause local leakage.