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Study Confirms Intensive Blood Pressure Management Reduces Dementia Risk

Four-year randomized trial in rural China demonstrates a 15% reduction in dementia and 16% in mild cognitive impairment through targeted hypertension care.

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Close-up of a tonometer with digital readings of pulse, heartbeat, blood pressure, medical concept, emphasis on the numbers of the tonometer, the woman's face is not visible.
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Overview

  • The Nature Medicine trial involved nearly 34,000 adults aged 40 and older with uncontrolled hypertension across 326 rural Chinese villages.
  • Participants receiving intensive care saw their blood pressure drop significantly, with an average reduction to 127.6/72.6 mmHg, compared to 147.7/81.0 mmHg in the control group.
  • Over four years, the intervention group experienced a 15% lower incidence of all-cause dementia and a 16% lower risk of mild cognitive impairment compared to standard care.
  • The intervention included free or subsidized antihypertensive medications, lifestyle coaching, home monitoring, and tailored adherence support delivered by community healthcare providers.
  • Researchers recommend scaling up this proven intervention globally to address the growing burden of dementia, which is projected to triple by 2050.