Overview

• Researchers from the University of Sydney and collaborators in China created a dissolving microneedle patch using stevioside to carry and solubilize minoxidil.
• Topical minoxidil is approved for pattern hair loss but is limited by poor water solubility and skin permeability, which the patch is designed to overcome.
• In a testosterone-induced alopecia mouse model, the patch achieved hair regrowth over about 67% of the treated area by day 35 versus about 25% with standard topical minoxidil.
• The study, published October 8, 2025 in Advanced Healthcare Materials, also showed markedly improved minoxidil absorption into the skin.
• Authors caution the findings are preclinical and say they will investigate the mechanism and pursue clinical trials, noting stevia’s widespread food use as supportive background rather than proof of safety for this application.