Overview

• Switching glucose for galactose in stem cell cultures forces a metabolic shift to oxidative phosphorylation, reprogramming cells into a more youthful state.
• The reprogramming activates NAD⁺-dependent sirtuin deacetylases, enhancing cell identity and reducing transcriptional noise through epigenetic remodeling.
• Rejuvenated 'super stem cells' demonstrate superior differentiation capacity and sustained cellular health compared to standard stem cells.
• Potential applications include improving IVF success rates by enhancing embryo implantation through better yolk sac lineage formation.
• Researchers are exploring broader regenerative medicine uses, such as revitalizing aging cells and treating diseases like Parkinson's, diabetes, and heart failure.