Overview

• The study leveraged the MIMIC-IV database to compare 6,070 statin-treated sepsis patients with 6,070 matched controls using propensity score matching.
• Statin use corresponded with a drop in 28-day all-cause mortality from 23.4% to 14.3%, representing a 39% relative reduction.
• Patients receiving statins experienced an average increase of three hours on mechanical ventilation and 26 hours of continuous renal replacement therapy.
• Survival benefits held for patients with normal, overweight and obese body mass indices but were not observed in underweight individuals.
• Investigators urge large-scale randomized controlled trials to validate these observational findings and determine optimal statin protocols in sepsis care.