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Stanford’s Milli-Spinner Clot-Densifying Device Nears Human Trials

With suction-driven rotational shear compressing fibrin networks to shrink clots by up to 95%, the device accelerates removal after achieving outstanding preclinical success.

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Overview

  • The milli-spinner employs a rotating hollow catheter with fins and slits to generate localized suction and shear that compresses clots in place, reducing their volume by as much as 95%.
  • In flow-model experiments and swine studies, the device more than doubled first-pass reperfusion and achieved a 90% first-try success rate against fibrin-rich thrombi.
  • By densifying rather than fragmenting clots, the technology minimizes downstream emboli and preserves vessel integrity compared with conventional aspiration or stent-retriever tools.
  • A Stanford-licensed spin-out has been formed to advance the technology toward initial human clinical trials planned for the near future.
  • Beyond ischemic stroke applications, researchers are exploring the milli-spinner’s potential to remove pulmonary embolisms, treat heart attacks and even extract kidney stone fragments.