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Stanford Spray-Drying Method Could Turn Many IV Biologics Into Quick Injections

The Science Translational Medicine paper details MoNi‑coated, spray‑dried protein microparticles that maintained injectability at ultra‑high concentrations in laboratory evaluations.

Overview

  • Bench tests produced injectable suspensions exceeding 500 mg/mL for albumin, human immunoglobulin, and a COVID‑19 monoclonal antibody.
  • The MoNi polyacrylamide copolymer forms a glassy coating that keeps proteins dry and prevents aggregation, yielding smooth, spherical microparticles that flow through standard needles.
  • Formulations showed robustness in stress studies, including 10 freeze–thaw cycles and storage at elevated temperatures without signs of breakdown.
  • Researchers note MoNi has shown no adverse effects in preclinical models, though human trials have not yet begun.
  • The platform has been licensed to a local startup to refine the process and advance toward manufacturing scale‑up and regulatory testing.