Overview
- Los Angeles (6-2) travels to Levi's Stadium to face San Francisco (6-3) on Sunday at 4:25 p.m. ET, with most books listing the Rams as road favorites and totals among Week 10's highest.
- Matthew Stafford leads the NFL with 21 touchdown passes and has guided a three-game Rams win streak, while Los Angeles ranks second in scoring defense after allowing just 20 points across its last three games.
- San Francisco continues without Nick Bosa, Mykel Williams and Fred Warner for the season, Mac Jones is 5-2 as the starter with Brock Purdy still limited, and edge rusher Bryce Huff is expected back.
- Christian McCaffrey tops the league in touches and scrimmage yards and was featured underneath in the first meeting, as the 49ers pair a top-three third-down rate with red-zone inefficiency.
- Puka Nacua is expected to play through a rib issue and CB Darious Williams is tracking to return for L.A., with the rivalry renewed after the 49ers' 26-23 overtime win in Week 5 and a recent trend of underdogs covering in this series.