Overview

• Published September 22, 2025, the peer-reviewed work identifies phosphatidylserine enrichment on phagosome membranes as the initiating cue for LAP.
• The lipid signal recruits a Rubicon-containing PI3-kinase complex, launching the enzymatic cascade that decorates phagosomes with LC3.
• The study provides the first evidence that a specific membrane lipid regulates LAP activation across diverse triggers such as dead cells and antibody-coated particles.
• Prior research from the same group showed that blocking LAP can bolster anticancer responses, framing this mechanism as a potential therapeutic target.
• The experimental study, led by Doug Green and first author Emilio Boada-Romero at St. Jude, lists NIH, EMBO and ALSAC support and reports the findings under DOI 10.1038/s41556-025-01749-z.