Overview
- The Detroit Lions edged the New Orleans Saints 31-30 in overtime on Sunday after Amon-Ra St. Brown hauled in two touchdown passes and caught the game-winner in OT.
- The Baltimore Ravens routed the Indianapolis Colts 41-23 as Derrick Henry rushed for three touchdowns and more than 140 yards, lifting his career rushing totals up the all-time list.
- The Buffalo Bills beat the Houston Texans 36-31 with Josh Allen passing for 334 yards and accounting for four total touchdowns while German rookie Marlin Klein recorded his first NFL catch.
- The Jacksonville Jaguars dominated the Cleveland Browns 34-10 as Trevor Lawrence threw four touchdown passes and Deshaun Watson struggled under pressure with an interception and multiple sacks.
- Early availability concerns surfaced after Week 1 with Kyler Murray diagnosed with a concussion and other injuries to skill players, a development that could quickly affect depth, playcalling and short-term playoff hopes.