Overview

• Week 5 introduces the first byes, narrowing the betting slate with mostly interconference matchups and Bills–Patriots the lone Sunday divisional game.
• The SportsLine computer model simulates every game 10,000 times, reports well over $7,000 in gains for $100 players on top-rated picks, and enters this week on a 39-20 run.
• The model lists the Saints (-1.5, 42) to cover against the Giants, projecting a strong edge for New Orleans in a Sunday afternoon kickoff.
• It also backs the Cardinals (-7.5, 41.5) over the Titans in well over half of simulations and projects the Over to hit in nearly 60% of scenarios.
• Key lines on the board include Colts -7 vs. Raiders, Eagles -4.5 vs. Broncos, Seahawks -3 vs. Buccaneers, Bills -8 vs. Patriots on Sunday night, and Chiefs -3.5 vs. Jaguars on Monday, with bettors weighing injuries to Lamar Jackson and CeeDee Lamb alongside fresh expert props and picks from Matt Severance, Doug Kralstein, Daniel Vithlani, and R.J. White.