Overview

• The donor’s sperm spanned 67 births across eight European countries between 2008 and 2015 before the TP53 mutation was uncovered.
• Ten of his children have developed serious cancers, including brain tumors, leukemia, Hodgkin lymphoma and non-Hodgkin lymphoma.
• Thirteen additional offspring have tested positive for the TP53 gene variant associated with Li-Fraumeni syndrome and elevated cancer risk.
• Affected children now undergo regular whole-body MRIs, brain scans and abdominal ultrasounds to detect tumors at an early stage.
• Calls are growing for EU-wide donor limits and stronger genetic screening protocols to prevent future cases.