Overview

• AEMPS issued a warning based on ANSM data that using ibuprofen at 400 mg or higher doses without medical supervision can trigger heart attacks or strokes, especially in people with hypertension or existing heart disease.
• New studies indicate that taking paracetamol at standard doses (1 g every 8 hours) for two weeks can raise blood pressure in patients with coronary disease, challenging its reputation as a benign analgesic.
• Experts recommend using the lowest effective dose of both ibuprofen and paracetamol for the shortest duration necessary under healthcare supervision to reduce cardiovascular and gastrointestinal risks.
• Patients with histories of stomach ulcers, renal or liver problems, hypertension or pregnancy in the third trimester should avoid ibuprofen, and those with liver issues should limit paracetamol.
• Metamizol (Nolotil) is advised as an alternative for intense pain relief without the cardiovascular or gastrointestinal toxicity linked to ibuprofen and paracetamol.