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Soft Bioelectronic Mesh Tracks Embryonic Brain Development

It matches the softness of growing neural tissue to record single-neuron signals with millisecond precision without harming embryos.

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Overview

  • Researchers at Harvard SEAS developed a stretchable bioelectronic mesh from fluorinated elastomers and implanted it into tadpole and axolotl embryos' neural plates.
  • The device integrates into developing brains to capture electrical activity from single neurons at millisecond resolution.
  • In vivo trials confirmed that the implant does not disrupt normal embryonic growth or behavior.
  • Preliminary compatibility tests suggest the technology could be applied to mouse embryos and neonatal rats for broader vertebrate research.
  • Harvard has licensed the core materials to Axoft, a startup co-founded by Jia Liu, aiming to scale the soft bioelectronics for studies of neurodevelopmental disorders.