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3w ago

Smoked and Edible Cannabis Use Impairs Vascular Health, Study Finds

Impaired endothelial function linked to cannabis use raises cardiovascular event risk, highlighting need for long-term research.

Employees inspect cannabis plants at cannabis grower Hollandse Hoogtes, where regulated cannabis cultivation takes place in a grow center, in Bemmel, Netherlands, on April 1, 2025.
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Sunnyside Chews cannabis edible gummies at a Cresco Labs Inc. facility in Indiantown, Florida, U.S., on Monday, March 28, 2022. A bright spot in the beleaguered legal-cannabis industry may be U.S. multistate operators, which we expect to lead the group's 1Q year-over-year sales growth, largely reflecting their expansion in U.S. state-legal markets. Photographer: Eva Marie Uzcategui/Bloomberg via Getty Images
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Overview

  • A JAMA Cardiology study of 55 otherwise healthy adults found regular marijuana smokers had a 42% reduction in vascular function and THC-edible users a 56% reduction compared to nonusers.
  • Serum from marijuana smokers reduced nitric oxide production in cultured endothelial cells by 27%, whereas THC-edible users’ serum showed no such effect.
  • Higher frequency and potency of cannabis consumption correlated with greater endothelial dysfunction, indicating a dose-dependent relationship.
  • Previous analyses of over 4.6 million adults under age 50 linked cannabis use to up to a sixfold higher risk of heart attack and a fourfold increase in ischemic stroke.
  • Researchers urge clinicians to include cannabis use in cardiovascular risk assessments and call for larger, long-term studies to determine safe usage levels.