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Smallest 3D Bioprinter Demonstrated for In‑Situ Vocal Fold Repair

The elephant‑trunk soft robot fits through a laryngoscope to place hyaluronic‑acid gel with millimeter accuracy.

Overview

  • The McGill‑led device uses a 2.7 mm printhead—the smallest reported bioprinter—on a tendon‑controlled flexible arm with manual controls mounted on a surgical microscope.
  • In surgical simulators, the printer was fed through a standard scope and deposited hydrogel onto artificial vocal folds with repeatable precision, producing ~1.2 mm lines within a ~20 mm workspace.
  • The approach targets a key surgical challenge by enabling precise in‑mouth placement of hydrogels to help limit postoperative scarring and stiffness after lesion removal.
  • Researchers reported accurate reconstruction of vocal‑fold geometry in training models, from localized cavities to full‑fold repairs.
  • The study was published Oct. 29 in Device, and the team plans animal testing and is developing semi‑autonomous control as steps toward human clinical trials.