Overview

• Offering a guaranteed $25 Amazon gift card increased sign-ups to the Alzheimer Prevention Trials Webstudy by nearly 40% versus a message-only invitation.
• Entry into a drawing for a $2,500 Amazon gift card with 1-in-100 odds did not raise enrollment compared with the control group.
• Nearly 50,000 adults aged 50 and older without dementia in an integrated county health system serving primarily Medicaid enrollees were randomized to the three outreach arms.
• Response to the $25 incentive was strongest among participants who were white, male, or enrolled in Medicaid, underscoring representation challenges.
• The randomized study, conducted by ATRIL and published Aug. 22 in JAMA Health Forum, informs ongoing ethical and policy debates over the use and size of financial incentives in clinical research recruitment.