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Sleeping Fruit Flies Reveal Brain Filter That Lets Strong Signals Break Through

Charité scientists map dual visual circuits that create brief slow‑wave windows for strong stimuli.

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Overview

  • The Nature study finds an inhibitory visual network blocks routine sensory processing during sleep while a competing activating network remains poised.
  • Particularly strong inputs can bypass the inhibition and wake the animal, consistent with the researchers’ “open window” model.
  • The team links these openings to short periods between slow, synchronous electrical waves when high voltage may permit information flow.
  • Experiments in Drosophila at Charité in Berlin were led by David Owald with Davide Raccuglia and Raquel Suaréz‑Grimalt, leveraging the fly’s compact ~200,000‑neuron brain.
  • Authors suggest possible parallels to human thalamic sensory gating and emphasize that confirming such links will require further research.