Overview

• The Lancet Primary Care paper evaluates 4,823 Oxfordshire patients referred to SCAN between 2017 and 2023.
• In the cohort, 8.8% received a cancer diagnosis and 10.9% were diagnosed with serious non-cancer disease.
• Clinically significant incidental findings appeared in 19.3% of patients, highlighting added follow-up workload for services.
• Risk rose sharply with certain tests and symptoms, including a 29.7% positive predictive value for cancer with abnormal CA125.
• Developed with NHS England and charities, SCAN has been standard regional care since 2020 and study authors plan follow-up analyses and cost-effectiveness work before wider scale-up.