Overview

• A study published June 12, 2025 in Cell Stem Cell demonstrates that PGE2 treatment reverses age-related muscle stem cell dysfunction in mice.
• A single dose of PGE2 fully restored stem cell activity in aged muscles and yielded lasting gains in regeneration and strength.
• Aging was shown to reduce both PGE2 levels and EP4 receptor expression on muscle stem cells, impairing their repair signaling.
• PGE2 modulated key transcription factors to flip genes altered by aging back to youthful patterns.
• Researchers now plan to investigate PGE2’s applications in regenerating other tissues commonly weakened by aging.