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Simons Foundation Launches $80 Million, 10‑Year Brain Energetics Collaboration

The effort will combine new metabolic sensors and large‑scale computational models to reveal how energy supply limits shape neural computation.

Overview

  • The Simons Collaboration on Brain Energetics launched in early November 2026 with $80 million committed over 10 years to a team of 26 investigators led by Thomas Clandinin.
  • The Institute of Science and Technology Austria’s Tim Vogels received a $3 million award to build computational models that link mitochondrial energy metabolism to neuronal activity and learning.
  • SCOBE will concentrate on four research areas: single‑cell energetics, energetics across circuits, neurovascular coupling, and adaptation to energy scarcity.
  • Researchers will run coordinated, cross‑laboratory experiments across worms, flies, mice and humans while developing new sensors for metabolites and sharing data openly to validate models.
  • Organizers expect the work to sharpen how scientists read neuroimaging signals, explain how metabolic stress affects brain function, and guide future studies of development, aging and neurological disorders.