Overview
- A study published in Nature on April 2, 2025, shows a 20% lower risk of dementia among individuals vaccinated against shingles, based on a natural experiment in Wales.
- The study utilized an age-based eligibility cutoff from Wales' 2013 shingles vaccination program, providing robust comparative data to minimize biases.
- Researchers propose that the vaccine may reduce dementia risk by preventing viral reactivation, reducing inflammation, or through broader immune system effects.
- Women experienced stronger protective effects from the vaccine, potentially due to differences in immune responses, highlighting gender-specific benefits.
- Calls for randomized controlled trials are growing to confirm the findings, explore underlying mechanisms, and assess the potential of newer vaccines like Shingrix.