Particle.news
Download on the App Store
3 ARTICLES
·
2w ago

Sham-Controlled Korean Trial Finds Low-Dose Radiotherapy Eases Knee Osteoarthritis Pain

Early results suggest the 3 Gy regimen could offer a middle-ground option for patients with mild-to-moderate disease who are not ready for surgery.

Image
Low-dose radiation treatment may delay knee replacement surgery in people with osteoarthritis

Overview

  • Four-month data presented at the ASTRO meeting showed 70% of patients receiving 3 Gy over six sessions met responder criteria versus 42% with sham treatment (p=0.014).
  • The multicenter randomized trial enrolled 114 people with primary knee osteoarthritis and assigned them to 3 Gy, 0.3 Gy, or sham across six sessions.
  • The very low-dose 0.3 Gy arm did not differ significantly from sham, indicating the therapeutic effect was driven by the 3 Gy dose.
  • No radiation-related side effects were reported, and investigators noted the regimen uses a small fraction of doses typical in cancer care.
  • Researchers restricted analgesics to acetaminophen during follow-up to limit confounding, and they are completing 12-month assessments with larger and comparative trials planned.