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Self-Powered Microneedle Patch Collects Blood-Free Biomarker Samples as Human Tests Begin

The passive design pulls interstitial fluid into a paper strip via glycerol-driven osmotic flow for later analysis.

Researchers have developed a microneedle patch to monitor a range of health biomarkers without drawing blood or relying on batteries or external devices. In proof-of-concept testing with synthetic skin, the researchers demonstrated that the patches could collect biomarker samples in as little as 15 minutes.
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Overview

  • Proof-of-concept studies on synthetic-skin models collected measurable samples in as little as 15 minutes and preserved them for at least 24 hours.
  • The four-layer patch integrates swelling microneedles, a paper collector, and a glycerol gel that drives battery-free flow through osmotic pressure.
  • Cortisol served as the test biomarker, and the team built an electronic reader that quantifies cortisol directly from the paper strip.
  • Researchers report that human testing has started and that additional reader devices for other biomarkers are in development.
  • The work is published in Lab on a Chip with NSF ASSIST and other support, and the lead author discloses a role with DermiSense as the team seeks industry partners.