Overview
- The game kicks off at 4:05 p.m. ET (1:05 p.m. PT) on KCPQ FOX with streaming available on NFL+ and major providers.
- Seattle starts new quarterback Sam Darnold, who now faces the 49ers after previous stints in San Francisco and Minnesota.
- San Francisco rolls out a reworked front led by Nick Bosa, with Bryce Huff and rookie Mykel Williams joining under Saleh’s return as defensive coordinator.
- Bosa said he wants to “be dominant” and is “aiming for everything” after the 49ers fell to 29th in points allowed last season.
- Seattle seeks its first Lumen Field win over San Francisco since 2021 as the franchise marks its 50th season and targets a playoff return.