Overview
- Sportsbooks listed Seahawks −6.5 to −7 vs. the 49ers, Rams favored on the road at the Bears, and the Bills as slight favorites at the Broncos, with the Patriots awaiting the Texans–Steelers winner.
- Early totals settled in the mid‑40s to low‑50s, including roughly 45.5–46.5 for 49ers–Seahawks and about 51.5 for Rams–Bears, per BetMGM and DraftKings as of Jan. 12.
- One betting outlet advised taking the Under 46.5 now for San Francisco at Seattle after a recent 13–3 meeting and given venue and weather considerations in the Pacific Northwest.
- Rams–Bears opened around Los Angeles −4.5, with guidance to consider waiting because the half‑point off the key number of 4 could shift and moneylines may offer better value.
- Market notes cite factors such as a reported Achilles injury to 49ers TE George Kittle, Matthew Stafford playing through a finger issue, travel, and potential winter conditions in Chicago.