Overview

• Scripps Research and collaborators report the method in Science Advances, with the paper dated August 15, 2025.
• The Structure-to-Sequence workflow pairs cryo-electron microscopy maps with the ModelAngelo AI tool to recover antibody gene sequences directly from immune sera.
• Antibodies identified by the pipeline provided significant protection in mouse influenza models, demonstrating preclinical proof of concept.
• The process trims discovery timelines from weeks to under a day and targets longstanding screening bottlenecks in antibody development.
• The team has begun broader collaborations to test the platform’s generalizability, supported by CEIRR and NIAID funding.