Scientists Use Ancient DNA to Recreate Dire Wolves After 10,000 Years

Colossal Biosciences announces the birth of three genetically engineered dire wolf pups, sparking discussions about conservation, authenticity, and the future of de-extinction.

• Colossal Biosciences has successfully engineered three dire wolf pups—Romulus, Remus, and Khaleesi—using ancient DNA and CRISPR technology.
• The pups, created through 20 targeted genetic edits to gray wolf DNA, are living in a secure 2,000-acre preserve under constant monitoring.
• The recreated dire wolves exhibit physical traits such as larger size, broader heads, and white coats, but experts question their genetic authenticity as true dire wolves.
• This breakthrough is part of Colossal's broader initiative to revive extinct species like the woolly mammoth and support conservation efforts for endangered animals such as red wolves.
• The achievement has drawn significant public and cultural attention, with 'Game of Thrones' creator George R. R. Martin and filmmaker Peter Jackson endorsing the project.

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