Scientists Unveil Programmable RNA-Guided Genome Editing Tool

New bridge recombinase mechanism allows precise DNA modifications, advancing beyond CRISPR capabilities.

Researchers at the Arc Institute discovered the bridge recombinase mechanism, a programmable tool for DNA recombination.
The system uses bridge RNA to specify target and donor DNA sequences, enabling precise genetic modifications.
This breakthrough allows for large-scale genome design, including insertions, deletions, and inversions of long DNA sequences.
The new method offers higher specificity and efficiency compared to traditional CRISPR-Cas systems.
The findings were published in Nature, showcasing the potential for advanced genetic engineering applications.