Overview

• Researchers demonstrated that recalling cold memories can autonomously trigger thermogenic responses in mice, even in warm environments.
• Hippocampal neuron ensembles, termed 'cold-memory engrams,' were identified as the key storage and relay centers for these experiences.
• Using optogenetics, scientists activated or inhibited these engram cells, showing direct control over metabolic responses, including body heat generation.
• Brown adipose tissue, or brown fat, was confirmed as the effector mechanism, activated via brain innervation during memory-driven thermogenesis.
• The findings open new possibilities for treating disorders like obesity and cancer by targeting memory-based thermoregulatory pathways.