Scientists Map Structure and Function of Advanced Gene-Editing Tool
New insights into the prime editor's spatial configuration and molecular mechanisms could revolutionize gene therapy.
- Researchers from the University of Tokyo have detailed the spatial structure of the prime editor, a novel gene-editing tool.
- The prime editor combines SpCas9 and reverse transcriptase to edit genes without cutting both DNA strands.
- Cryogenic electron microscopy was used to capture the complex's three-dimensional structure in multiple states.
- Findings may lead to the development of more accurate gene-editing tools for therapeutic applications.
- The study's results were published in the journal Nature.
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