Overview

• Researchers at the Garvan Institute mapped over 50,000 i-motifs in the human genome.
• These structures, once controversial, are now recognized as widespread and significant in gene regulation.
• I-motifs are linked with highly active genes and cancer-related oncogenes like MYC.
• Potential therapies could target i-motifs to influence gene expression and treat hard-to-cure cancers.
• The study demonstrates the power of advanced antibody tools in genomic research.