Scientists Engineer First Mouse with Two Fathers to Reach Adulthood

Chinese researchers used advanced stem cell techniques to overcome genetic barriers, marking a milestone in reproductive biology and regenerative medicine.

• Researchers from the Chinese Academy of Sciences successfully created a bi-paternal mouse that survived to adulthood, a first in mammalian reproduction science.
• The team modified 20 imprinting genes to address developmental barriers caused by genetic material from two male parents, significantly improving embryo viability.
• Approximately 13% of engineered embryos resulted in live births, though many exhibited developmental abnormalities, reduced lifespans, and sterility.
• The breakthrough provides insights into imprinting-related genetic disorders and could advance stem cell-based therapies and cloning techniques.
• Future research aims to refine the process and explore its application in larger mammals, though significant challenges remain.

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