Overview

• An international team led by Shoukhrat Mitalipov at Oregon Health & Science University reports the results in Nature Communications.
• Researchers transferred nuclei from skin cells into enucleated donor oocytes and used an experimental step called mitomeiosis to reduce chromosome number.
• The protocol generated up to 82 oocytes that were fertilized in vitro, with about 9% of resulting embryos developing to the blastocyst stage by day six.
• Most embryos arrested early and many blastocysts showed chromosomal abnormalities, highlighting low efficiency and unresolved safety concerns.
• External experts describe possible future uses for some infertility cases but emphasize that extensive research and regulatory review are needed before any clinical use.