Overview

• Defensive coordinator Robert Saleh said Jacksonville has a system to read signals within NFL rules that repeatedly puts its offense in favorable situations.
• San Francisco confirmed Nick Bosa is out for the season with a torn ACL, shifting pass‑rush duties to players such as Bryce Huff.
• Liam Coen emphasized patient play‑calling against the 49ers’ heavy use of quarters and cover‑6 shells designed to punish greedy decisions.
• Trevor Lawrence prioritized cutting penalties and cleaner third‑down execution after the Jaguars’ 17-10 win over Houston.
• Jacksonville enters 2-1 with an offense around 23.3 points per game, while the 3-0 49ers lean on Fred Warner’s all‑field impact on defense.